The correct answer is option 4, "Clrease." However, it should be noted that "Clrease" is not a known enzyme or a valid option. There seems to be an error in the provided answer.

Enzymes are biological catalysts that help speed up chemical reactions in living organisms. The first enzyme to be isolated in pure crystalline form was actually urease. In 1926, James B. Sumner successfully isolated urease from jack beans and obtained it in a pure crystalline form. Urase is an enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. Sumner`s isolation and crystallization of urease played a pivotal role in advancing the understanding of enzymes and their functions.