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The correct answer is option 1: Carbon monoxide. Tobacco smoke contains various harmful substances, including carbon monoxide, which is why it is considered injurious to health. Carbon monoxide is a poisonous gas that binds to hemoglobin in the blood, reducing its ability to carry oxygen to the body`s organs and tissues. This can lead to a range of health problems, such as reduced lung function, increased risk of heart disease, and damage to blood vessels. While options 2, 3, and 4 are also present in tobacco smoke, they are not the primary reason why tobacco smoke is harmful to health. Nicotine is addictive and can cause addiction-related health issues, polycyclic aromatic hydrocarbons are carcinogenic compounds, and melathene is not a known substance related to tobacco smoke.