The correct answer is option 1: Pancreas and gallbladder.

Secretin is a gastrointestinal hormone that is secreted by the duodenal epithelium. It functions to stimulate the secretion of pancreatic juice from the pancreas. Pancreatic juice contains enzymes that are necessary for the digestion and absorption of nutrients in the small intestine.

Cholecystokinin (CCK) is another gastrointestinal hormone that is also secreted by the duodenal epithelium. Its primary function is to stimulate the contraction of the gallbladder, which leads to the release of bile into the small intestine. Bile is important for the digestion and absorption of fats.

Therefore, the activation of these two hormones, secretin and cholecystokinin, leads to the activation of the pancreas and gallbladder to discharge their secretions, respectively. It is important to note that the activation of the stomach is not mentioned in the question, so option 3 (Pancreas and stomach) is incorrect.